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Savanna Journal of Basic and Applied Sciences 3(1):16-20
Effect of Oral Administration of Aqueous Extract of Cloves (Syzygium aromaticum) on Serum Lipid Profile in Wistar Rats
Bichi S.A., Dalhatu M.M. and Sule M.S.

ABSTRACT
Effect of oral administration of aqueous extract of Syzygium aromaticum on serum lipid profile and atherogenic indices were assessed in 32 apparently healthy male Wistar rats. The animals were randomly grouped which were grouped and administered with different doses (mg/kg) .as follows: Group A (normal diet without cholesterol-rich diet and extract), Group B (cholesterolrich diet), Group C (cholesterol-rich diet and 100 mg/kg of aqueous extract of S. aromaticum (AESA); Group D (cholesterol-rich diet and 200 mg/kg of AESA). Group E (cholesterol-rich diet and 400 mg/kg of AESA), Group F (normal diet and 100 mg/kg of AESA), Group G (normal diet and 200 mg/kg of AESA), Group H (normal diet and 400 mg/kg of AESA) for a period of four weeks. Animals that were fed with normal diet with the extract constituted the negative control group, and animal fed with cholesterol rich diet with the extract constituted the positive control group. At the end of the four weeks, the animals were sacrificed, serum lipid profile and Artherogenic indices were determined. Data was subjected to one-way analysis of variance (ANOVA) using Statistical Package for Social Sciences (SPSS 10.0) software. Duncan’s Multiple Range Test was used to establish significant differences (p˂0.05). Results revealed that mean serum LDL-cholesterol, Total-cholesterol and Triglycerides were lower in animals fed normal diet and 400mg/kg of aqueous extract of S. aromaticum compared to animals fed with normal diet and 100 mg/kg. Thus, it could be inferred that “aqueous extract of S. aromaticum” especially at 400 mg/kg may lower some cardio risk factors due to its antihyperlipidemic effect. P values less than 0.05 were considered significant. Mean serum LDL, T. Chol and TRIG levels were lower in animals fed normal diet and 400 mg/kg of aqueous extract of S. aromaticum compared to animals fed with normal diet and 100 mg/kg. Thus, it could be suggested that “aqueous extract of S. aromaticum” especially at 400 mg/kg could reduce some of the risk factors of cardiovascular disease.