This study investigated the incidence and antibiotic susceptibility pattern of urinary pathogens commonly isolated from patients suspected of UTI at Sir Yahaya Memorial Hospital Birnin Kebbi, Kebbi State Nigeria. Two hundred urine samples from patients suspected with urinary tract infection were collected, the causative organisms were isolated on CLED and blood agar and identified using macroscopy, microscopy and biochemical test and their antimicrobial susceptibility patterns were profiled using Kirby Bauer method. The overall incidence of UTI was found to be 31.5 Percent (63/200). Staphylococcus aureus 31/200 (15.5 Percent ), Klebsiella spp 20/200 (10 Percent ) and Proteus spp 12/200 (6 Percent ). Staphylococcus aureus, showed high percentage of susceptibility to the antibiotics viz; ampicillin (58.0 Percent ), amoxicillin (88 Percent ), cotrimoxazole (93.5 Percent ) and pefloxacin (96.8 Percent ), resistant to ceftazidime and gentamicin (83.9 Percent ), and ofloxacin and streptomycin (100 Percent ). Klebsiella spp was susceptible to amoxicillin (95 Percent ) and (100 Percent ) to ciprofloxacin but resistant to the seven remaining antibiotics. Proteus spp showed (100 Percent ) resistance to ampicillin, ciprofloxacin, cotrimoxazole and streptomycin, but susceptible to amoxicillin, ofloxacin, and pefloxacin (50 Percent ). In conclusion, the three isolated uropathogens were susceptible to amoxicillin (> 80 Percent ), resistant to streptomycin, ofloxacin and gentamicin ( less than 10 Percent ). Thus, routine surveillance and regular monitoring is required to establish reliable information about susceptibility pattern of urinary pathogens for optimal empirical therapy of patients with UTI.