The study investigated demographic precursors of spontaneous abortion and preventive strategies among childbearing mothers in Owerri Senatorial Zone, Imo State, Nigeria. Five research questions and three null hypotheses guided the study. The correlational research design was adopted for the study. The sample was 520 childbearing mothers (CBMs) drawn randomly from a population of 742,576 CBMs in Owerri Senatorial Zone, Imo State. Researchers’-structured Demographic Precursors of Spontaneous Abortion Questionnaire (DPSAQ) was used for data collection. Percentages were used to answer research questions one and five, phi ( ) correlation coefficient was used to answer research questions 2-4 while Chi-square (χ2) statistic was used to test the null hypotheses at .05 level of significance. The results among others indicated that CBMs had spontaneous abortion (32.2%). Level of education was significantly associated with spontaneous abortion. Age and parity were not significantly associated with spontaneous abortion among CBMs. Based on these findings; spontaneous abortion preventive strategies were formulated and adjudged appropriate by experts. Among the preventive strategies were health education of mothers on the danger signs of spontaneous abortion, such as: vaginal bleeding, abdominal pain and back pain, provision of pregnancy counseling to women that had spontaneous abortion in the past, and providing community health education to positively influence the knowledge of pregnant women towards PRCs such as spontaneous abortion using seminar, conferences, and health talks. The authors recommended among others that health educators should adopt appropriate preventive strategies to intensify awareness in order to reduce pregnancy-related complications and other maternal health problems.